Morphogen gradients: Nodal enters the stage

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Morphogen gradients: Nodal enters the stage

Morphogen gradients are proposed to organise cell fates during development via the long-range activity of secreted molecules. Their existence in vertebrates, however, has been debated. A recent study has identified the Nodal-related protein Squint as a bona fide morphogen in vertebrate mesoderm.

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The interpretation of morphogen gradients.

Morphogens act as graded positional cues that control cell fate specification in many developing tissues. This concept, in which a signalling gradient regulates differential gene expression in a concentration-dependent manner, provides a basis for understanding many patterning processes. It also raises several mechanistic issues, such as how responding cells perceive and interpret the concentra...

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Scaling of morphogen gradients.

Individuals of the same or closely related species can vary substantially in size. Still, the proportions within and between tissues are precisely kept. This adaptation of pattern with size termed scaling, is receiving a growing attention. We review experimental evidence for scaling, and describe theoretical models for mechanisms that scale morphogen gradients. We particularly note the Expansio...

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Shaping Morphogen Gradients

Shh activity and at different distances from the source. The proper functioning of tissues and organs requires These observations provide unequivocal evidence that that each cell differentiate appropriately for its position. Shh acts directly on distant cells and therefore that Shh In many cases, the positional information that instructs forms a morphogen gradient in the developing neural cells...

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Morphogen Gradients: Expand and Repress

An expansion-repression mechanism by which morphogen gradients can adjust to size and growth had been postulated as a model. Now, its molecular nature has been uncovered.

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ژورنال

عنوان ژورنال: Current Biology

سال: 2001

ISSN: 0960-9822

DOI: 10.1016/s0960-9822(01)00385-2